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in MPTP-induced PD models, markers of dopaminergic neuron necroptosis (such as phosphorylated MLKL) are significantly upregulated, and RIPK3 inhibition mitigates neuron loss [41]

After baseline subtraction (() control), the initial ATPase activity rate was determined via simple linear regression (linear range, GraphPad Prism 10) of time-dependent absorbance measurements and normalized to unmodified HpGroEL activity (100%)